Twenty people have been killed and 26 injured in a mass shooting at a Walmart store in the Texas city of El Paso.
Governor Greg Abbott described it as "one of the most deadly days in the history of Texas".
Police are investigating whether the attack, which happened a few miles from the US-Mexico border, was a hate crime.
A 21-year-old man is in custody. Police said the suspect lived in Allen, Dallas, about 650 miles (1,046km) east of El Paso.
He has been named by US media as Patrick Crusius.
CCTV images said to be of the gunman and broadcast on US media show a man in a dark T-shirt wearing ear protectors and brandishing an assault-style rifle.
It came less than 24 hours before another mass shooting in Dayton, Ohio, and less than a week after a teenage gunman killed three people at a California food festival.
The police and FBI are investigating whether an anonymous white nationalist "manifesto", shared on an online forum, was written by the gunman. The document claims the attack was targeted at the local Hispanic community.
The Walmart, which is near the Cielo Vista Mall, was full of shoppers buying back-to-school supplies at the time of the shooting.
US President Donald Trump described the attack as "an act of cowardice".
"I know that I stand with everyone in this country to condemn today's hateful act. There are no reasons or excuses that will ever justify killing innocent people," he wrote on Twitter.
The victims have not yet been named but Mexico's President Andres Manuel Lopez Obrador said three Mexicans were among the dead, according to Reuters news agency.
"We as a state unite in support of these victims and their family members," Mr Abbott said.
"We must do one thing today, one thing tomorrow and each and every day after this - we must unite."
El Paso Police Chief Greg Allen said reports of an active shooter were received at 10:39 local time (16:39 GMT), and law enforcement officers were on the scene within six minutes.
The 21-year-old is the only suspect in custody and police say no officers fired their weapons while arresting him.
Mr Allen said the ages of victims were "numerous" as he described the situation as "horrific".
El Paso Police Department had earlier tweeted that blood donations were "needed urgently".