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Theresa May said on Friday that she will step down as leader of the Conservative Party, and therefore prime minister, on June 7.
May spoke of her "deep regret" at being unable to deliver Brexit despite her best efforts.
The announcement came after she met with Sir Graham Brady, chairman of the influential 1922 Committee of Conservative backbench MPs.
"The Brexit referendum was a call for profound change in our country," she stressed. "I did my best to implement the will of the people."
Fighting back tears, she said she was "the second female prime minister, but not the last," adding it was "the honor of my life to serve the country I love."
She will remain in charge on a caretaker basis until a successor is found.
