Ivanka Trump is shuttering her clothing line in order to focus on her role as senior adviser in her father's White House, the company announced Tuesday.
The move comes over a year after she split from the company to enter the White House as a senior adviser.
Ms Trump launched the brand in 2014, but after her father's election was faced with boycotts from shoppers.
Ms Trump had reportedly become frustrated by the difficulties posed by avoiding possible conflicts of interest while serving in the White House.
A spokesperson for the company said the decision "has nothing to do with the performance of the brand and is based solely on Ivanka's decision to remain in Washington indefinitely."
After 17 months in her White House role Ms Trump said she did not know "when or if I will ever return to the business".
"But I do know that my focus for the foreseeable future will be the work I am doing here in Washington, so making this decision now is the only fair outcome for my team and partners," Ivanka Trump said in a statement.
"I am beyond grateful for the work of our incredible team who has inspired so many women; each other and myself included. While we will not continue our mission together, I know that each of them will thrive in their next chapter," she added.
Ms Trump's fashion career started with the launch of her jewellery brand in 2007. She developed seven categories ranging from footwear and handbags to eyewear and fragrance over the next six years.
Ms Trump herself imposed restrictions on how the company could operate when she moved to work for her father, including not expanding internationally and requiring the firm to obtain her approval before striking agreements with new domestic partners.
The company said these restrictions limited the company's ability to grow and meant winding down the business was the fairest option for the brand's partners and its employees.
The firm also said that Ms Trump would not agree to selling the brand since a third party was unlikely to adhere to the restrictions she had put in place.